In Vitro Antithrombotic, Antitumor and Antiangiogenic Activities of Green Tea Polyphenols and Its Main Constituent Epigallocatechin-3-gallate

The balance between embolic risk and bleeding represents a clinical challenge in cancer patient treatment, encouraging studies on adjuvant oncologic treatments. Thereby, this study evaluated the vitro effect of green tea extract (GTE) epigallocatechin-3-gallate (EGCG) hemostasis modulation antineoplastic melanoma cells (B16-F10) by applying platelet aggregation, angiogenesis viability cell assays. results displayed significant antiaggregant effect, corresponding to 50 80% for EGCG, respectively, compared negative control. Furthermore, both GTE EGCG exhibited antitumor effects reducing growth 25 50%, verified cellular apoptosis. Regarding angiogenesis, these substances inhibited blood vessel formation, reaching about 25% 99% at 100 μg/mL, respectively. Moreover, TNF-α stimulation evidenced VEGF IL-8 secretion inhibition 55 20% with GTE, while promoted an around 78% IL-8. indicate promising performance as option treating its side effects. Nonetheless, further are required elucidate their action mechanism clotting, death angiogenesis.